Friday, October 03, 2003

Research Breakthrough in Understanding Treatment-Resistant Depression (UK)
Press release from the Clinical Neuroscience Research Centre reprinted at Yahoo on research published in the latest in issue of Biological Psychiatry - "Around 5 million people in the UK experience depression at any one time. Whilst a number of successful treatments, both pharmacological and psychotherapeutic, are available and many people make a full recovery about 30 - 40% of people are resistant to conventional therapies. For them their depression is an enduring, debilitating disease and for some, the only treatment options left include psychosurgery and ECT. Now an international team of researchers have discovered that brain activity differs significantly between healthy individuals and those suffering from treatment-resistant clinical depression. ... The study, the most significant to date to have investigated dysfunction in different parts of the brain in treatment-resistant depression, also heralds a new era in drug development. There are already benchmark drugs for treatment-resistant schizophrenia, but there is no equivalent treatment for treatment-resistant depression at the moment. This development in the understanding of the biological basis of treatment-resistant depression gives hope to scientists searching for a much-needed 'atypical' antidepressant."