Easing Depression Without Drugs. Easing Depression Without Drugs Depression affects approximately 18.8 million adults in the U.S. and is the nation's leading cause of disability. Yet mental health experts say the front-line treatment for serious cases, antidepressant drugs, works only about half the time and can have troubling side effects, such as weight gain, sexual dysfunction, and even suicidal behavior. [...] [World of Psychology]000000comment []