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This Notice announces the availability of the final document, Guidelines for Carcinogen Risk Assessment. The Guidelines provide a framework to EPA scientists for assessing possible cancer risks from exposures to pollutants or other agents in the environment. They will also inform Agency decision makers and the public about these recommended procedures. Revisions to the Cancer Guidelines are intended to make greater use of the increasing scientific understanding of processes of cancer development. Major issues considered in finalizing revisions to the Cancer Guidelines were
- beginning with an analysis of available information, and invoking defaults if needed to address uncertainty or the absence of critical information;
- emphasizing key events and processes, starting with the interaction of an agent with a cell, through functional and anatomical changes, that may result in adverse health consequences ("modes of action");
- considering that certain subpopulations, and childhood and other lifestages, may be associated with higher susceptibilities to risk; and
- summarizing the full range of available evidence and describing any conditions associated with conclusions about an agent's hazard potential using a weight-of-evidence narrative and accompanying descriptors.
These Guidelines were developed as part of an Agency-wide guidelines development program by a Technical Panel of the U.S. EPA's Risk Assessment Forum, which was composed of scientists from throughout the Agency. Selected drafts were peer reviewed internally by the U.S. EPA's Science Advisory Board, and by experts from universities, environmental groups, industry and other governmental agencies. The Guidelines were also subjected to several public comment periods. Issuance of these final Guidelines fulfills EPA's obligations under section 112(o) (7) of the Clean Air Act.
For further information, go to http://www.epa.gov/cancerguidelines, or contact Dr. William P. Wood, Risk Assessment Forum, National Center for Environmental Assessment (8601D), U.S. Environmental Protection Agency, Washington DC 20460, telephone: (202) 564-3361; facsimile: (202) 565-0062; or e-mail: risk.forum@epamail.epa.gov. [ChemAlliance Environmental News]
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