Biomedical Breakthrough: Predicting Protein Inhibitors

Locus Discovery's elegant computational approach of designing small molecules that can inhibit protein function requires that structure of the protein is known. 

The problem is that we know the structure of less than 1% of all proteins.  Locus' approach requires the correct protein structure to predict the small molecules that are likely to fit in the right binding pockets to change the protein's function.  To predict the affinity of a small molecule for a binding pocket requires emerging biosimulation software and massive computational power.  The result will be a much faster lead screening process than the current which still relies on technicians armed with machines in the lab. 

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