Updated: 3/27/08; 6:32:30 PM.
A Man with a Ph.D. - Richard Gayle's Blog
Thoughts on biotech, knowledge creation and Web 2.0
        

Thursday, August 16, 2007


I guess it's not just Andrew Wakefield who doesn't do controls when running PCR.

Remember a couple of months ago, when I discussed testimony at the Autism Omnibus trial that showed how Andrew Wakefield had failed to do the controls when running PCR that would have revealed that the results that he interpreted as the presence of the measles virus from a vaccine strain in the guts of autistic children was nothing more than a bunch of false positives due to widespread contamination of the laboratory with plasmid containing measles sequences?

It turns out that it's not just autism pseudoscientists who forget to do the right controls when running PCR. Mike the Mad Biologist describes an example of a very similar sloppiness of experimental technique in the microbiology world that also lead to what is almost certainly a false positive result.

I just can't understand how such obvious, first year graduate student mistakes manage to get published in the peer-reviewed literature. It doesn't happen that often, but it does happen at a rate that is high enough to be distressing. In the case of Andrew Wakefield, the results of his sloppy science were catastrophic, namely an antivaccination scare about the MMR that nine years later still hasn't fully run its course.

Read the comments on this post... [Respectful Insolence]

Usually it is good to do the control BEFORE you submit the paper for publication. And usually the reviewers will notice such a mistake.  10:45:07 PM    



Erasing memory in rats gives dementia patients hope. LONDON (Reuters) - Researchers have found a way to erase long-term memory in rats without damaging their brains in a study that could lead to targeted drugs for people suffering from dementia. [Reuters: Science]

Sounds like the beginning of a Jim Carrey movie.  10:11:32 PM    



 
August 2007
Sun Mon Tue Wed Thu Fri Sat
      1 2 3 4
5 6 7 8 9 10 11
12 13 14 15 16 17 18
19 20 21 22 23 24 25
26 27 28 29 30 31  
Feb   Jan






Click here to visit the Radio UserLand website.
Subscribe to "A Man with a Ph.D. - Richard Gayle's Blog" in Radio UserLand.

Click to see the XML version of this web page.

Click here to send an email to the editor of this weblog.


© Copyright 2008 Richard Gayle.
Last update: 3/27/08; 6:32:30 PM.