Tuesday, April 16, 2002

No, we won't tell you what "Dr. Bonzo" or "The Boulder Inquisition" really mean.  As noted above, if we told you what it (they) meant, we'd have to burn you.  But we will tell you what Bonzo does not refer to here: Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV coreceptors. An orphan G protein-coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV coreceptor (1-4). Bonzo/STRL33 is used by SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes. (From a product sheet [PDF] for the polyclonal antibody Anti - Bonzo (CT) STRL33, sold by ProSci, Incorporated.) Ain't Google wunnerful? 1:13:35 AM

Increasingly professionals in many fields are adopting a technology that until recently was considered to be largely the province of insomniac teen diarists and technology geeks. [MSNBC.com via Dan Gillmor's eJournal] As we say here at Inquisition H.Q., "Hoo ya!" 12:28:18 AM