At Randy Reichardt's The Pod Bay Door (found through Waypath) there is an entry from last week on colorblindness. An anonymous commentor takes Reichardt to task for having inaccessible colors on his site, so the color scheme of the site was changed to accommodate the roughly four and a half percent of us who are colorblind.
Colorblindness is a way of seeing that results in pictures of the world being presented in a different yet aesthetically pleasing palette. I used Visicheck's software to look at this page. The results were surprising: photographic art work was very close to the original, but links were too light and spectral colors were too dim.
Designers should be cautious - canned solutions can often ruin the look of your page and not really do much to improve your site's accessibility if used without the kind of color vision that deuteranopic retina provide.